This was less attributable to cardiovascular mortality (HR 0.87 95% CI 0.72-1.05), than to noncardiovascular mortality (HR 0.77 95% CI 0.65-0.90). Overall, ALT was inversely associated with all-cause mortality (hazard ratio 0.81 95% confidence interval 0.72-0.92), independently of potential confounders. During median follow-up for 11.1 (6.1-14.0) years, 553 (47%) patients died, with 238 (20%) attributable to cardiovascular causes. In 1187 patients with type 2 diabetes (67 ± 12 years, 45% female), ALT levels were 11 (8-16) U/L. Cox regression analyses were performed to determine the associations of log2 -transformed baseline ALT with all-cause, cardiovascular and noncardiovascular mortality. We therefore investigated the association of ALT with all-cause, cardiovascular and noncardiovascular mortality in patients with type 2 diabetes.Ī prospective study was performed in patients with type 2 diabetes, treated in primary care, participating in the Zwolle Outpatient Diabetes project Integrating Available Care (ZODIAC) study. Little is known about the association of ALT with mortality in patients with type 2 diabetes. Combined data suggest a bimodal association of alanine aminotransferase (ALT) with mortality in the general population.
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